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There are multiple metformin alternatives available such as Prandin (repaglinide), which is a meglitinide used to control blood sugar. Invokana (canagliflozin) is a drug that lowers blood sugar and reduces the risk of cardiovascular disease, as does Farxiga (dapagliflozin). The American Diabetes Association recommends metformin as a first-choice medicine to treat T2DM. You more Grapefruit juice may increase the blood levels of certain medications such as desogestrel. 3 They also recommend using a glucagon-like peptide-1 (GLP-1) agonist if weight loss is warranted Examples of Organic Supplement Options to Metformin Berberine This natural extract is derived from various plants. To make sure it's safe for you, tell your doctor before starting the medicine if you: have ever had an allergic reaction to metformin or other medicine; have uncontrolled. However, no herb is a proven alternative to metformin The American Diabetes Association/European Association for the Study of Diabetes recommend a sulfonylurea, meglitinide, pioglitazone, or dipeptidyl peptidase 4 (DPP-4) inhibitor when metformin cannot be used. Berberine helps to reduce blood sugar levels and to regenerate the cells responsible for the production of insulin. Berberine 4 Limited studies have found that berberine may be as effective as metformin in reducing blood sugar. It can also help improve cardiovascular health Some currently available combination drugs include Janumet (Januvia + metformin), Kombiglyze XR (Onglyza + metformin extended release), and Synjardy (Jardiance + metformin). Metformin is not suitable for some people. You may more Disease Interactions Lactic acidosis. It is also sometimes used in combination with exercise and weight loss in people with prediabetes. But a growing number of health experts believe those days are behind us. It serves as an anti-inflammatory, antioxidant, and antimicrobial. Some evidence suggests that a few herbs might mimic some of the effects of metformin. Most adults and children aged 10 years and older can take metformin. Who may not be able to take metformin.